Faculty

Janice Blum, Ph.D.

Modulation of T cell immunity by viral infections, autophagy
Full profile

Dr. Blum’s research examines the role of hematopoietic cells in immunity. Her laboratory has define the importance of autophagy in regulating immunity.  Her team has also examines the role of hematopoietic cells in autoimmune diabetes and metabolic disorders. She also studies functional defects in hematopoietic cells in immune-deficient patients.


Michael E. Boulton, Ph.D., FARVO

Vascular biology, cell signaling and oxidative damage
Full profile

The Boulton laboratory is investigating the use of bone marrow-derived cells (BMDC) in the treatment of age-related macular degeneration. We are maximizing therapeutic utilization of BMDC by genetic programming prior to injection into the systemic circulation, their injection at the time of optimal engraftment potential and preconditioning of the retina.


Hal Broxmeyer, Ph.D.

Regulation of self-renewal, differentiation, apoptosis & homing/migration of HSC
Full profile

The laboratory focuses on mechanisms regulating the growth, self-renewal, survival, differentiation, and homing/mobilization of hematopoietic stem and progenitor cells, embryonic stem cells and induced pluripotent stem cells at cellular, intracellular, and animal levels, and cytokine/chemokine actions, and immune cell regulation for translation for clinical utility.


Randy Brutkiewicz, Ph.D.

Immune evasion, antigen presentation, signal transduction in innate & adaptive immunity
Full profile

The Brutkiewicz laboratory studies immune evasion by tumors, in the context of the regulation of antigen presentation by various signal transduction pathways, in both innate and adaptive immune responses, including MHC class I and MHC class II molecules, as well as the CD1d/NKT cell axis.


Rebecca J. Chan, M.D., Ph.D.

Functional role of mutant Shp-2 in murine HSC growth and cytokine response
Full profile

The Chan lab has a long history focusing on the protein tyrosine phosphatase, Shp2, and its role in embryonic stem cell function and hematopoietic stem cell self-renewal.  We are carrying these studies forward by studying mutant Shp2 function in macrophage biology and in innate immunity influencing the bone marrow microenvironment.


D. Wade Clapp, M.D.

Molecular pathogenesis of Fanconi anemia & neurofibromatosis
Full profile

My laboratory focus on understanding the molecular pathogenesis of NF1 and particularly the role of immune cells in tumor initiation and progression.  We utilize a combined approach of using GEMMs and bone marrow transplantation to identify molecular and pharmacologic targets to treat the benign tumors in mice and in humans.


Alexander Dent, Ph.D.

Growth and differentiation of T cells
Full profile

My lab studies the regulation of the antibody response, and specifically the T helper cells that are required for helping B cells. Our work has implications for controlling autoimmune diseases such as lupus, and also for helping to develop vaccines that can target infectious diseases as well as cancer cells.


Linda Anne DiMeglio, M.D., MPH

Type 1 diabetes and metabolic bone diseases. Diabetes biomarkers
Full profile

The Grant lab focuses on the impact of diabetes on vascular repair mechanisms and the impact of diabetes-induced denervation on bone marrow function. Our studies seek to understand the molecular mechanisms responsible for the phenotypic and functional changes in CD34+ cells that occur in individuals that develop microvascular complication.


Kenneth Dunn, Ph.D.

Kidney microtubules function in diabetic patients
Full profile

The research of my laboratory is broadly focused on the development of methods of quantitative microscopy, particularly intravital microscopy.  Current projects include development of fluorescent protein biosensors for in vivo studies, development of methods of automated digital image analysis and intravital microscopy studies of the dynamics of drug-induced liver injury.


Sherif Farag, M.D., Ph.D.

Cord blood and marrow HSC transplantation. NK cell function in transplant recipients
Full profile


W. Scott Goebel, M.D, Ph.D.

Mechanisms of engraftment of transduced HSC in sub-myeloablated murine hosts
Full profile

My research seeks to develop novel cellular and gene therapies for non-malignant diseases, especially Fanconi anemia. Two patients have been treated with mesenchymal stem cells to enhance hematopoietic engraftment and prevent graft-vs-host disease.  A gene therapy trial for Fanconi type A patients has been funded, with regulatory approval pending.


Maria B. Grant, M.D., FARVO

Control of circadian regulation of bone marrow cell release in health and diabetes
Full profile

The Grant lab is focusing on understanding the molecular mechanisms responsible for the phenotypic and functional changes in CD34+ cells that occur in individuals that develop microvascular complications.  Our studies have resulted in development of therapeutic strategies that are currently in preclinical and clinical trials for use diabetic retinopathy and diabetic macular ischemia.


Samir Gupta, M.D.

HIV and cardiovascular disease
Full profile

Dr. Gupta conducts clinical and translational research in new HIV treatment strategies and methods to reduce chronic co-morbidities in HIV-infected persons. He currently holds NIH grants focused on depression treatment to reduce systemic inflammation and improve cardiovascular risk and also on the role of inflammatory monocytes on endothelial colony forming cells. He also supports the research of other groups by performing in vivo vascular imaging and providing clinical samples from HIV-infected patients within the IU Health medical system.


Laura Haneline, M.D.

How mutations in the Fanconi anemia genes perturb HSC function
Full profile

Dr. Haneline examines how abnormal intrauterine environments alter fetal stem/progenitor function. Maternal diabetes leads to profound functional deficits in fetal hematopoietic stem/progenitors and endothelial colony forming cells. Current studies are interrogating epigenetic alterations that promote dysregulated gene expression and vasculogenesis. Translational studies evaluate circulating progenitors as biomarkers of endothelial dysfunction.


Melissa Kacena, Ph.D.

Role of osteoblasts in hematopoietic niche. Impact of megakaryocytes on osteogenesis
Full profile

Our research focuses on the regulatory interactions between skeletal and hematopoietic cells  in 3 main areas: 1) The effects of megakaryocytes on osteoblast proliferation and bone formation; 2) The regulation of bone regeneration by thrombopoietin; and 3) The regulation of hematopoietic stem cells by osteoblasts, megkaryocytes, and osteal macrophages.


Mark Kaplan, Ph.D.

Immunobiology of STAT proteins; cytokines promoting T helper effector functions
Full profile

Research in the Kaplan lab focuses on understanding the development and function of T helper cell subsets that impact autoimmunity and allergic disease. The lab is particularly interested in understanding the role of transcription factors during the decision process for acquisition of a specific inflammatory phenotype in the T cell.


Reuben Kapur, Ph.D.

Molecular mechanisms involved in normal and abnormal hematopoiesis
Full profile

We study signaling pathways involved in regulating normal hematopoiesis as well as non-malignant hematologic diseases. Specifically, we study how PI3Kinase and Rho family GTPases ROCK and Rap1 contribute to stem and progenitor cell functions. We also study the role of stress MAPKinase pathways in normal and stress hematopoiesis.


Yan Liu, Ph.D.

Role of p53 and Bmi in HSC self-renewal
Full profile

The Liu laboratory is interested in investigating the molecular mechanisms that regulate hematopoietic stem cell self-renewal in normal and leukemic hematopoiesis. Research in the Liu lab is currently focused on determining the role of the role of mutant p53 and phosphatase PRL2 in leukemia stem cell self-renewal and leukemogenesis.


Christie Orschell, Ph.D.

Acute and delayed effects of radiation exposure on the hematopoietic system and hematopoietic stem cell biology
Full profile

Dr. Orschell is a radiobiologist/experimental hematologist focused on understanding and developing mitigation strategies for the hematopoietic acute radiation syndrome and the delayed effects of acute radiation exposure on the hematopoietic system and others.


Sophie Paczesny, M.D., Ph.D.

T cell regulation in GVHD disease
Full profile

Conducting proteomic discovery studies, I have made seminal contributions to identification of biomarkers associated with graft-versus-host disease (GVHD), and validated them in independent cohorts, thus providing the highest level of evidence for their clinical significance. Another research interest is to understand how effective antitumor immunity is generated.


Louis Pelus, Ph.D.

Bioactive cytokines/growth factor control of HSC proliferation & migration
Full profile

The Pelus lab focuses on  hematopoietic stem cell  self-renewal, differentiation and trafficking and how these processes  are regulated by the bone marrow niche.  Using genetically modified mice, pharmacological agents and in vivo imaging, the laboratory identified  key roles for prostaglandin E2 and neuropeptide Y in regulation of stem cell function and trafficking and is exploring their roles in  aging and response to radiation exposure.


Karen E. Pollok, Ph.D.

Immunotherapy and DNA repair
Full profile

Our research on normal hematopoiesis is to discover mechanistically how human hematopoietic cells respond to genotoxic stress. We are using ex-vivo expanded myeloid precursor cells and humanized bone marrow mouse models to interrogate molecular mechanisms and develop strategies to protect these life-sustaining cells from the deleterious effects of genotoxic stress.


Edward F. Srour, Ph.D.

Hematopoietic microenvironment; cell cycle regulation and engraftment of HSC
Full profile

The Srour research focuses on the impact of interactions between hematopoietic stem cells (HSC) and cellular elements of the hematopoietic niche on the maintenance and function of HSC. This research centers on how osteoblasts, osteolineage macrophages, and megakaryocytes maintain the stem cell pool and how CD166 bridges these cells together.


Mervin Yoder, M.D.

Endothelial cell regulation of proliferation and differentiation of HSC
Full profile

The Yoder laboratory is focused on identifying the regulatory pathways modulating the cells involved in vascular formation, remodeling, and repair and have identified endothelial colony forming cells (ECFC) as critical elements. We are now focusing on the therapeutic effects of ECFC when implanted in immunodeficient animal models of vascular ischemic injuries.

 

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